Fragile X Syndrome: The GABAergic System and Circuit Dysfunction

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Fragile X syndrome: the GABAergic system and circuit dysfunction.

Fragile X syndrome (FXS) is a neurodevelopmental disorder characterized by intellectual disability, sensory hypersensitivity, and high incidences of autism spectrum disorders and epilepsy. These phenotypes are suggestive of defects in neural circuit development and imbalances in excitatory glutamatergic and inhibitory GABAergic neurotransmission. While alterations in excitatory synapse function...

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Many neurological disorders, including neurodevelopmental disorders, report hypersynchrony of neuronal networks. These alterations in neuronal synchronization suggest a link to the function of inhibitory interneurons. In Fragile X Syndrome (FXS), it has been reported that altered synchronization may underlie hyperexcitability, cognitive dysfunction and provide a link to the increased incidence ...

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ژورنال

عنوان ژورنال: Developmental Neuroscience

سال: 2011

ISSN: 1421-9859,0378-5866

DOI: 10.1159/000329420